Post Date December, 02 2023
I believe that many parents are most concerned about the issue of pediatric nephrotic syndrome: how to provide effective treatment? Currently, many children may develop nephrotic syndrome at birth, so timely treatment can save the lives of patients. Currently, many scholars believe that symptomatic supportive therapy is very suitable for children.
Symptomatic supportive therapy mainly includes several aspects, but specific treatment is mainly based on the symptoms of children. Firstly, it involves infusion of plasma, human immunoglobulin, etc., commonly used in pediatric nephrotic syndrome patients with recurrent infections. This treatment for nephrotic syndrome in children can also use low molecular dextran: 50~200ml/d, once a day, which can reduce blood viscosity and prevent thrombosis. Diuretic therapy promotes the work of children's urinary system by using some drugs to achieve the purpose of treating children's nephrotic syndrome.
There is another common method, but there is also a lot of controversy, which is the intravenous infusion of human blood albumin therapy: this treatment method for pediatric nephrotic syndrome is currently controversial. In the past, it has been believed that infusion of human blood albumin can supplement the loss of protein in the urine, and after infusion, furosemide (furosemide) can achieve good diuretic effect. Recently, reports suggest that infusion of human blood albumin>20g/d can cause protein overload nephropathy, Injury to glomerular epithelial cells can lead to two adverse consequences in patients with minimal variant kidney disease after infusion of human serum albumin: firstly, human serum albumin infusion interferes with the pharmacokinetics of prednisone, thus delaying the response to corticosteroid treatment; secondly, it may be due to human serum albumin infusion damaging glomerular epithelial cells, resulting in a long-term and sustained pathological change, manifested as frequent recurrence.
In summary, the treatment of pediatric nephrotic syndrome varies significantly due to different causes, and doctors need to make targeted choices based on the patient's symptoms, which is also the basic principle supporting treatment.
