Post Date December, 02 2023
Some miscarriages are related to men
Mr. Liu is puzzled: Can poor sperm lead to miscarriage? The doctor told Mr. Liu that the high rate of sperm DNA fragments may be the culprit leading to his wife's miscarriage. "The rate of sperm DNA fragments is high, just like the yolk of an egg has dispersed. Sperm that looks good may have internal quality problems, which can lead to poor embryo quality and easy miscarriage.". Therefore, abortion is not only a matter for women, but also for men with poor sperm.
Even if fertilized, it can easily lead to miscarriage
The integrity of sperm DNA is significantly correlated with sperm function and can affect the division of fertilized eggs and the development of embryos. DNA is located in the nucleus of sperm and is a carrier of genetic information, located similar to the yolk of an egg. "After sperm DNA damage, although it appears to be" good ", its function deteriorates. Although it does not affect egg fertilization, it can easily lead to poor embryo development and miscarriage.". In patients with severe sperm DNA damage, even if the egg can be fertilized and divided normally, it can still lead to miscarriage.
Sperm DNA fragment rate should be tested for three types of men
Traditional semen routine testing can reflect semen quality from aspects such as sperm concentration and motility, but its value in evaluating sperm function is limited and cannot directly reflect sperm fertilization ability and the impact on embryo development.
Research has shown that the sperm DNA fragment rate of infertile patients is significantly higher than that of normal people. Even if other semen indicators are normal, it does not mean that the sperm DNA fragment rate is normal. There are many patients with normal semen analysis results who were previously diagnosed as unexplained infertility, but now their sperm DNA fragment rate is high. After targeted treatment, they have obtained reproductive opportunities. Therefore, the detection of sperm DNA fragment rate is very important for infertile patients.
Especially for infertile patients who are preparing to use expensive IVF techniques, testing for sperm DNA fragment rates is particularly important because research has shown that it has a significant relationship with IVF success rates.
The first generation in vitro fertilization (IVF) technology requires fully functional sperm to successfully fertilize, and high sperm DNA fragment rates may lead to a decline in sperm fertilization ability, leading to egg fertilization failure.
The second generation in vitro infant technology (ICSI) can inject sperm directly into an egg, and DNA damaged sperm may also fertilize the egg and develop into an embryo. However, DNA damaged sperm can lead to poor embryo quality after fertilization, resulting in severe disruption of embryo development, which can lead to embryo implantation failure and embryo development defects, ultimately leading to miscarriage.
Therefore, it is recommended to test the sperm DNA fragment rate for male patients with a history of spontaneous abortion, unexplained infertility, and patients preparing for IVF. Men who want to undergo a prenatal and fertility test before pregnancy can also test the sperm DNA fragment rate in order to detect problems and treat them as soon as possible. Currently, many large reproductive centers, including the Reproductive Center of the First Affiliated Hospital of Sun Yat-sen University, have already implemented sperm DNA fragment rate testing programs.
The fragmentation rate can be reduced
Poor living habits such as smoking, drug abuse, alcoholism, and staying up late, long-term exposure to polluted air, high heat, toxins, and radiation in the work environment, genital gland infections and inflammation (epididymitis, orchitis, prostatitis, or seminal vesiculitis, etc.), increased white blood cells in semen, varicocele, and other diseases are all harmful factors that lead to increased sperm DNA fragment rates.
First, we should correct bad living habits (smoking, drug abuse, alcohol abuse, staying up late, etc.), regulate work pressure, and improve sleep quality; Avoid long-term exposure to harmful environments such as high temperatures, contaminated air, toxins, and radiation exposure.
Then, under the guidance of professional male doctors, treat related physical diseases, such as the use of antibiotics to treat genital gland infection and inflammation, surgical treatment of varicocele, Chinese medicine or traditional Chinese patent medicines and simple preparations, vitamin E and vitamin C and other drugs and some trace elements, which also help to reduce the rate of sperm DNA fragments. These treatments can help patients successfully produce healthy babies.
