Post Date November, 16 2024
Polycystic ovary syndrome is a familiar gynecological disease that also occurs in our daily lives. We must clarify its causes and prevent it with reasonable lifestyle habits in daily life.
The causes of polycystic ovary syndrome
1. Genetic factors: Experts believe that PCOS is a hereditary disease, possibly a concomitant dominant inheritance. Most patients have normal 46, XX karyotypes. Chromosome abnormalities are characterized by the absence of the long arm of the x chromosome and chimerism with abnormal number and structure of the x chromosome.
2. Abnormal paracrine control mechanism of ovarian partial secretion: Currently, many scholars speculate that there are substances such as epidermal growth factor transforming growth factor a and inhibin in the follicles of PCOS patients, which inhibit the sensitivity of granulosa cells to FSH, increase their own FSH threshold, and hinder the selection and further development of dominant follicles. That is to say, the abnormal control mechanism of partial paracrine secretion in the ovary hinders the selection of dominant follicles, which is the cause of PCOS.
3. The causes of polycystic ovary syndrome include hyperprolactinemia: approximately 20% to 30% of PCOS patients are accompanied by hyperprolactinemia. Some people believe that PRL can stimulate the secretion of androgens by adrenal cortical cells, as there are PRL receptors on the membrane of adrenal cortical cells.
4. Hypothalamic pituitary dysfunction: Patients with high LH values and normal or low FSH values have a ratio of LH/FSH exceeding 3, resulting in an increased response of LH to synthesized luteinizing hormone releasing hormone. Therefore, abnormal hypothalamic pituitary function is the starting factor for this syndrome. The increase in LH levels not only increases the pulse amplitude but also the frequency, which may be due to excessive peripheral androgens and aromatase converting into excessive androgens, Continue to interfere with the function of the hypothalamic pituitary gland.
5. Insulin resistance and hyperinsulinemia: Currently, it is believed that insulin resistance and hyperinsulinemia are common manifestations of PCOS. The increase in insulin levels in women with PCOS can increase ovarian androgen synthesis, and the increase in androgen activity significantly affects the stability of glucose and insulin internal environment. PCOS patients with hyperandrogenism, regardless of whether they are obese or not, are accompanied by significant insulin resistance even if their menstrual cycle is normal.
Hazards of polycystic ovary syndrome
1. Secondary infertility: Polycystic ovary syndrome (PCOS) is often characterized by anovulatory infertility, which is clearly manifested as amenorrhea. The reason is that the wall of the ovarian sac is too thick, and the egg cannot be expelled and cannot combine with sperm, which is the main cause of female infertility.
