How is hydatidiform mole formed? Three types of women should pay attention to prevention

The emergence of raisins has caused great distress to many women, and it is also a disease that we should pay attention to, especially when preparing for pregnancy. We should also pay attention to reasonable prevention in daily life.

How is hydatidiform mole formed

The hydatidiform mole is also known as a vesicular mole. The hydatidiform mole is named after the proliferation of placental villous trophoblasts and interstitial edema after pregnancy, resulting in the formation of blisters of different sizes. The blisters are connected into a string, shaped like grapes. The exact cause of hydatidiform mole is currently unknown and is generally believed to be related to factors such as nutritional disorders (especially folic acid deficiency), infections (especially viral infections), genetic and immune dysfunction.

After pregnancy, the embryo produces a lot of villi, which are implanted in the mother's uterus. The fetus exchanges substances with the mother and child through these large amounts of villi, obtaining oxygen, nutrition, and metabolism. In pathological cases, there is swelling between the villi, containing a large amount of transparent plasma. The body actively increases, and all villi become swollen blisters, with a diameter of generally 0.2-0.5 centimeters

The reason for raisins

1. Nutritional factors: Raisins are commonly found in gourmet countries and therefore related to nutrition. Studies have found that patients with gestational trophoblastic tumors (GTT) have low serum folate activity, but insufficient folate during embryonic angiogenesis can affect thymus synthesis, leading to embryonic death and insufficient blood vessels in placental villi

2. Infection factors: Many authors believe that raisins are related to viral infection, but no real evidence has been found so far.

3. Endocrine imbalance: The occurrence of raisins is related to inadequate or declining ovarian function, and is therefore more common in women under 20 years old and over 40 years old. Animal experiments have shown that removing ovaries in early pregnancy can turn the placenta into a blister sample, so insufficient estrogen may be the cause of raisins.

4. Pregnant egg defect: it may be related to the dysplasia of the egg itself.

5. Ethnic factors: the differences in the incidence rate of raisins among different races are of concern. It is reported that the incidence rate of raisins among African American women is only half that of other women. In Singapore, the incidence rate of hydatidiform mole of Eurasian race is twice as high as that of Chinese, Indian and Malaysian.

6. Overexpression of proto-oncogenes and inactivation of tumor suppressor genes: Proto-oncogenes and tumor suppressor genes are genes that control cell growth and differentiation. Activation and overexpression of proto-oncogenes, as well as inactivation of tumor suppressor genes, are related to the occurrence of tumors..