Post Date December, 03 2023
When treating male infertility, sometimes aspirin can also be used. There is a 35 year old male patient who came to see a doctor from another city and did not take contraceptive measures for 6 years. After hospital examination, there were no reproductive tract infections such as prostatitis. Computer analysis of semen showed that except for slightly fewer A-grade sperm (23%), all others were normal. His wife underwent gynecological examination and showed no abnormalities. She had taken traditional Chinese medicine in the local area for nearly a year and did not conceive her. The post test result of MAR (sperm mixed agglutination reaction) is positive, indicating the presence of anti sperm antibodies, and the diagnosis is immunological infertility.
The World Health Organization (WHO) report shows that immune infertility accounts for approximately 2% of male infertility. 7%。 This is due to the presence of anti sperm antibodies (AsAb) in the patient's body. AsAb, on the other hand, has adverse effects on sperm such as agglutination and immobilization, which can cause a large number of latex particles to adhere to the surface of sperm, making it unable to swim and lose the ability to converge with the egg, resulting in infertility.
In clinical practice, steroid hormones and immunosuppressants can be used in infertility cases with positive anti sperm antibodies, among which prednisone is a commonly used drug. Scholars have initially proposed high-dose pulse therapy, such as taking 60 milligrams of prednisone orally daily for 7 days. However, more serious complications such as gastrointestinal bleeding may occur, and are now being abandoned. The author used a small dose of prednisone (5 mg/day) and orally administered enteric coated aspirin (25 mg/day) for 3 consecutive months. After 3 months, their anti sperm antibodies turned negative, and their wife became pregnant six months later.
Aspirin is an old medicine that has been around for over a hundred years and is a non steroidal anti-inflammatory drug. It is originally used for antipyretic, analgesic, and anti rheumatic purposes. And research has found that this drug can also inhibit agglutination by inhibiting the cyclooxygenase of platelets and reducing the production of prostaglandins. Therefore, it is used to prevent thrombosis and also to treat unstable angina. The treatment of immune infertility also utilizes its anti agglutination effect to prevent latex particles from adhering to the surface of sperm, so that sperm can "lay down their burdens and go to battle lightly", swim towards the egg as soon as possible and fertilize it.
Due to the use of enteric coated aspirin and its small dosage, although it has been used for up to 3 months, there are very few adverse reactions. However, patients with active peptic ulcer disease and those who are allergic to the drug are still contraindicated; Do not take it if there is a tendency for bleeding.
In addition, AsAb positive patients caused by reproductive tract infections should be treated with appropriate antibiotics.
