What drugs easily lead to impotence in men? Can antihypertensive drugs cause impotence

According to foreign reports, about 25% of the outpatients of internal medicine suffer from drug-related impotence. In recent years, the trend of ED caused by drugs has increased significantly, which cannot be ignored. In order to enable both doctors and patients to cause drug treatment for ED, in order to reduce unnecessary misunderstanding and strengthen prevention, the commonly used clinical drugs that have a certain impact on male sexual function are introduced as follows:

Antihypertensive drugs acting on the center

The inhibitory effect of methyldopa on sexual function is proportional to the dose. For example, if the dose of each drug is less than 1 gram, the daily dose of male patients with 10% - 15% ED is 1 to 1. 5 grams, 20%~25% of patients have sexual dysfunction, and the daily dose is greater than or equal to 2 grams, and 50% of patients may have obvious sexual dysfunction.

Antihypertensive drugs act on vascular smooth muscle

The daily oral dose of hydrabendazine is more than 200 mg, and the patient has 5% - 10% ED.

Antipsychotics

It can cause ED of chlorpromazine, methylthiazide, fluperphenazine and fluperidol.

Antimanic depression

Lithium carbonate, imipramine, amitriptyline, clomipramine, etc. ED。

Antihistamine

Long-term use of cimetidine and ranitidine will lead to ED, and the incidence of cimetidine users is high.

Anticholinergics

When used in large doses, it can cause ED of atropine, mountain alkaloid, prubenosin and benhexol (antan).

Cardiac glycosides

Long-term use of digitalis and digoxin will lead to ED.

Hormone drugs

Both methyltestosterone and testosterone propionate have the effect of chemical emasculation, male testicles atrophy, and sperm production decreases. Long-term use of estradiol, ethinyl estrone and chlorprogesterone in men will lead to estrogen ED; Adrenal corticosteroids can directly or indirectly reduce the level of serum testosterone, leading to ED.

Antipyretic analgesic

When taking indomethacin (indomethacin) for a long time, it will occasionally cause indomethacin ED; Testicular atrophy, inhibition of spermatogenesis, and male infertility are the long-term high-dose application of phenacetin and baltasone.

Antitumor drugs

At present, most anti-tumor drugs can cause progressive ED, and anti-tumor drugs can directly damage the structure and function of testis.

If the patient really needs to take the above drugs, he/she should weigh the advantages and disadvantages, master the time and dose of medication, try to avoid the impact of drugs on sexual function, and stop medication in time or use other drugs for treatment in case of ED symptoms. In general, drug-induced ED can gradually return to normal 3~6 months after drug withdrawal.