What are the predisposing factors of endometrial cancer? 9 types of women should be careful of endometrial cancer

The emergence of endometrial cancer has brought serious harm to patients, not only affecting their normal life and work, but also threatening their health and life safety. We must pay attention to its causes.

Causes of endometrial carcinoma

1. Anovulatory functional blood: those with functional uterine bleeding of anovulatory type or luteal dysfunction have long-term menstrual disorder, endometrium continues to be stimulated by estrogen, progesterone antagonism and progesterone deficiency, and endometrial periodic changes are insufficient

2. Infertility: especially infertility caused by ovarian anovulation, the risk of endometrial cancer is significantly increased. Among patients with endometrial cancer, about 15% - 20% of patients have a history of infertility. These patients do not ovulate or ovulate less, progesterone is insufficient or insufficient, and the endometrium is continuously stimulated by estrogen. During pregnancy, the placenta produces estrogen and pregnancy hormone, which changes the pregnancy period of endometrium. During lactation, due to the role of the hypothalamus and pituitary, the ovarian function is temporarily inhibited, and the endometrium is not stimulated by estrogen. The endometrium of infertile people, especially those who do not ovulate, is in a proliferative state for a long time.

3. Obesity: Excessive obesity will cause endometrial cancer. For female friends, too much fat will increase the storage of estrogen, and androstenedione in plasma will become estrone. This increase in free active estrone may be a carcinogen or pro-cancer factor of endometrial cancer.

4. Late amenorrhea: The risk of endometrial cancer in women with amenorrhea over 52 years old is 1.5~2.5 times that in women with amenorrhea before 45 years old. The amenorrhea does not ovulate after several years, but only prolongs the action time of estrogen. Late menarche is a protective effect on endometrial cancer, especially for premenopausal women, late menarche can reduce the potential of endometrial cancer by 50%, and late menarche can reduce the persistent stimulation of estrogen on endometrium.

5. Polycystic ovarian syndrome: about 19%~25% of patients with endometrial cancer under 40 years of age suffer from polycystic ovarian syndrome. Patients with polycystic ovarian syndrome have long ovarian filtration time, but immature ovulation. Endometrium is stimulated by continuous estrogen, progesterone regulation and periodic endometrial exfoliation

6. Long-term continuous stimulation of estrogen on endometrium: related to anovulatory dysfunctional uterine bleeding, polycystic ovarian syndrome, functional ovarian tumor, long-term use of estrogen after menopause, and difficulty in progesterone.