There are many pathogenic factors for endometrial cancer, and eight types of women should pay attention to prevention

Endometrial cancer is a well-known gynecological disease and one of the major diseases. We must clarify its pathogenic factors and actively prevent it in daily life.

Causes of endometrial cancer

1. Obesity: Excessive fat can increase the storage of estrogen, and testosterone in plasma can become estrone. This increase in free active estrone may be a carcinogenic or pro oncogenic factor in endometrial cancer.

2. Diabetes: diabetes patients or those with abnormal glucose tolerance have an increased risk of endometrial cancer by 2. 8x.

3. Hypertension: There are more cases of endometrial cancer with hypertension.

4. Menstrual disorders: Patients with endometrial cancer have menstrual disorders and high menstrual volume, which are three times higher than normal women.

5. Early menarche and late amenorrhea: The incidence of endometrial cancer is 60% higher in those who have menarche before the age of 12 compared to those who have menarche after the age of 12. The young age of endometrial cancer is 6 years later than that of ordinary women.

6. Number of pregnancies and deliveries: Endometrial cancer often occurs in those who are multiparous, not giving birth, or infertile.

7. Polycystic ovary syndrome: Without ovulation, the endometrium undergoes proliferation changes due to insufficient regulation of pregnancy hormones and periodic endometrial dissection under high and sustained levels of estrogen.

8. Ovarian tumors: Granulocytic carcinoma, follicular thecoma, etc. that secrete high levels of estrogen, with irregular menstruation, bleeding after amenorrhea, endometrial hyperplasia, and endometrial cancer.

9. Atypical hyperplasia of the endometrium: stage of endometrial cancer development or absence of this stage. Severe atypical proliferation can be considered as endometrial carcinoma in situ.

10. Exogenous estrogen: Women who take estrogen have a high risk of endometrial cancer, which is related to dosage, duration of use, whether pregnancy hormones are used in combination, discontinuation of medication, and patient characteristics. After discontinuing the medication, the risk decreased in gray, but the risk continued for several years. At present, there is sufficient evidence of a causal relationship between estrogen and endometrial cancer.

High risk population for endometrial cancer

1. Infertility: A high-risk factor for endometrial cancer, with a decrease in risk as the number of deliveries increases. Infertility caused by long-term anovulation is more likely to occur in women who have given birth to one child. Patients with polycystic ovary syndrome are also prone to developing this disease due to the same reasons.

2. People who take exogenous estrogen for a long time due to various reasons: those who only use exogenous estrogen without pregnancy hormone antagonism can increase the risk of developing endometrial cancer, which is related to the dosage and duration of estrogen use. Adding pregnancy hormone antagonism can reduce the risk.