Post Date December, 03 2023
Different treatment methods are selected based on the different causes of oligospermia:
(1) Treatment of oligospermia caused by endocrine dysfunction: Some patients can increase their sperm count by taking clomiphene, 25mg per day, 25 days per month, 5 days off, and 6-12 months as a course of treatment. There are reports that long-term use can reduce the percentage of sperm with normal morphology, so it is currently recommended to use low-dose therapy, which is 25mg every other day. Human chorionic gonadotropin (HCG) 1000u is also used, with intramuscular injection twice a week for 8-10 weeks as a course of treatment; At the same time, it is recommended to take vitamin E 100-200mg orally daily for 3-4 months. Testosterone propionate 50mg has also been tried, with intramuscular injections three times a week for a total of three months. During the medication, the sperm count decreased or disappeared, and rebound phenomenon occurred after discontinuation. However, the efficacy has been reported to be poor. Recently, it has been reported that the use of ketotifen (meperidothioheptanone) 1mg twice a day for 3 months has significantly improved sperm density and motility. The addition of pentoxifylline to semen or oral administration can increase the vitality of sperm with insufficient motility in idiopathic oligozoospermia.
(2) Varicocele is the most common cause of oligospermia, with reports reaching as high as 39%. It can be treated with varicocele ligation, with an increase in sperm density of about 50% to 80% one year after surgery and a pregnancy of about 30% to 50% in wives.
(3) Acute and chronic orchitis, epididymitis, prostatitis, seminal vesiculitis, and other reproductive tract inflammations are also common causes of oligospermia. Carboxybenzylpenicillin can be treated by taking 4 grams of it daily, divided into 4 doses, and used continuously for 1 month. Compound neolamine can be penetrated into prostatic fluid, and the effect is also good. Take 2 tablets twice a day for 3 months.
(4) Supplement trace elements: Zinc supplementation has a certain therapeutic effect on oligospermia and azoospermia, and the number of sperm significantly increases after taking the medicine. Due to the antagonism of zinc and copper, zinc supplementation also treats high copper. The treatment method is to orally take 50-100mg of zinc gluconate twice a day for a period of 3 months, and there are also cases where zinc sulfate is used for treatment.
(5) Arginine supplementation: arginine is a necessary component for sperm production, and the amino acid content in the semen of oligospermia patients is significantly lower than that of normal males. Replenishing arginine by taking 4 grams orally daily for 10 weeks can increase sperm count.
(6) Traditional Chinese medicine can be tried with Wuzi Dihuang Tang: 9g goji berries, 12g each of dodder seed, raspberry fruit, and plantain seed (bag), 4.5g each of Schisandra chinensis, 12g each of Alisma orientalis, Angelica sinensis, and Poria cocos, 4.5g each of licorice, and 12g each of Huaishan yam, Danpi, white peony, raw earth, and Codonopsis pilosula. Water decoction, one dose per day, 100 doses per course of treatment. After treatment, abnormal semen can restore the fertility rate to 56.2%.
(Intern Editor: Cai Junyi)
