Post Date November, 17 2024
Non liquefaction of semen is one of the common causes of male infertility, accounting for approximately 1.2% to 11.8% of male infertility. Non liquefied semen affects sperm motility and viability, reduces the ability of sperm to penetrate cervical mucus, and leads to infertility. So, what should I do if I suffer from non liquefaction of semen?
The ejaculated semen of a normal male is gelatinous and changes from a viscous state to a liquefied state after 5-20 minutes. After ejaculation, if the semen fails to fully liquefy at room temperature (25 ℃) for 60 minutes, it is called non liquefaction or delayed liquefaction of semen.
The coagulation and liquefaction process of semen is completed by the joint participation of secretions from the prostate and seminal vesicles. Semen coagulation is caused by coagulation factors produced by the seminal vesicles, while semen liquefaction is caused by liquefaction factors such as proteolytic enzymes produced by the prostate. When the balance between liquefaction and coagulation factors is disrupted, semen can exhibit abnormal liquefaction.
One of the common reasons for semen non liquefaction is Prostatitis. Inflammatory cell infiltration, fibrous tissue hyperplasia, glandular tubule edema and obstruction in the prostate tissue of patients, decreased prostatic secretion activity, and changes in the quality and quantity of prostatic fluid secretion, resulting in changes in enzymes and seminal plasma components in seminal plasma, such as Prostate-specific antigen (PSA), Acid phosphatase (ACP), Urokinase (uPA), citric acid Reduction of trace elements such as zinc and changes in pH value. The above components have the activity of semen liquefaction factors and directly participate in the liquefaction process of semen. As a result, the coordinated relationship between semen coagulation and liquefaction is disrupted, leading to abnormal liquefaction.
The treatment of abnormal semen liquefaction aims to improve prostate secretion function. The main methods are traditional Chinese medicine to improve prostate secretion function, supplement trace elements, regulate semen pH, and use antibiotics to control infection.
The content of trace element zinc in prostate fluid and semen is significantly higher than that in other tissues and body fluids. The zinc content in normal semen is about 100 times higher than that in plasma, and the zinc in seminal plasma is mainly secreted by the prostate gland. Low zinc can reduce the activity of semen proteases, thereby reducing the liquefaction effect of semen proteases and causing abnormal semen liquefaction.
Zinc is an important anti infective factor in the prostate, and the synthesis of over 100 enzymes in the human body requires zinc to participate. The liquefaction of semen requires the normal amount of zinc secreted by the prostate, and the synthesis of sufficient protease liquefaction factors can achieve normal semen liquefaction. In chronic Prostatitis, the content of zinc in the prostate tissue is significantly reduced, and the liquefaction factors secreted and synthesized by the prostate are also significantly reduced, leading to non liquefaction of semen and decline of sperm vitality, thus leading to male infertility. Therefore, patients with non liquefaction of semen can also be treated with zinc supplementation as a trace element.
