Post Date December, 02 2023
Pseudohermaphroditism refers to a child having only one gonadal system in their body. Women with only the ovaries are called pseudohermaphrodites, and their chromosome karyotype is 46, xx. What causes pseudohermaphroditism? Presumably, this is an issue that everyone is very concerned about and concerned about, so today we will briefly introduce it to everyone in response to their questions. Next, let's listen to the introduction to this issue!
1. sex chromosome aberration In the process of embryonic development, the sex organ differentiates into male or female, and its decisive factor is initially controlled by genetic factors, such as the karyotype of newborn individuals is 46, xx, that is, they develop into female; If the karyotype is 46, xy, it develops into a male. Because there is a genetic gene on the Y chromosome that determines the differentiation of the original gonad into the testis, but this gene is absent on the x chromosome. If the number and structure of sex chromosome are distorted, it will inevitably lead to Sexual differentiation disorder.
2. Abnormal androgen secretion in embryonic stage When the primitive gonad differentiates into testis under the control of genetic factors, its cortex degenerates, but its medulla develops well, so both interstitial cells and adrenal cortex produce a considerable amount of androgen. Due to the action of male hormones, the primordial reproductive ducts and external genital primordia differentiate towards the male direction.
3. Other factors of pseudohermaphroditism The decrease of the number of embryonic primordial germ cell can also make genetic women masculinization. The reduction of the number of primitive germ cell can cause the development of the cortex of the primitive gonad to be blocked, the deep medulla forms the testicular component, and the interstitial cells produce androgen, which makes the primordial genital duct and external genital primordium differentiate toward the male direction.
After reading the above article, everyone has gained a certain understanding of the causes of pseudohermaphroditism. Do you feel that sexual deformities are not so mysterious? I hope patients with sexual deformities do not worry too much and must actively treat them with a good attitude.
